Opioids are a family of laced drugs that include both illegal drugs like heroin, legal painkiller medications like oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, and morphine, and synthetic drugs like fentanyl. It is important to note that although opioids relieve pain, they are not categorized with more mainstream over-the-counter painkiller medications like aspirin and Tylenol.
Opioids bind to specific receptors called opioid receptors in the human nervous system and can be addictive as they not only relieve pain, but provide a sensation of euphoria as well. While some opioids are prescribed by doctors for pain relief in serious circumstances, regular use can lead to addiction and dependence. As a result of regular use, many individuals have experienced overdoses that led to their death. Fortunately, medications like naloxone can reverse an opioid overdose when administered immediately; however, it is not an entirely foolproof solution.
The opioid crisis has its roots in the 1990s when healthcare providers began to prescribe opioid painkillers at higher rates to patients, which was in part due to the reassurance from pharmaceutical companies regarding the safety and efficacy of opioid painkillers. As a result of the increased use and circulation of opioid medications, misuse has become more common. In the past year alone, 1.6 million people in the United States had an opioid use disorder, 745,000 people used heroin, 2 million people used methamphetamine, and 10.1 million people misused prescription opioids. This increase in misuse has resulted in what we call the opioid epidemic.
- Opioids are a family of laced drugs that include both legal drugs (oxycodone, vicodin, etc.) and illegal substances (heroin, fentanyl).
- The rate of deaths by overdose has been increasing in the past decade, and an increasing amount of these deaths are attributed to synthetic drugs such as fentanyl.
- Congress has passed some important legislation such as the SUPPORT act, and many community organizations have made attempts to slow the spread of the opioid epidemic.
- The treatment of opioid use disorder is predicted to become more difficult if the COVID-19 pandemic continues.
- There is significant partisan conflict on how to properly prevent crises such as these, as well as how to slow the spread of the current epidemic.
- Recent legislation financially discourages the sale of opioids and attempts to address the rising prevalence of fentanyl.
The rate of deaths by overdose has more than quadrupled in the last decade. In 2019, over 70% of drug overdose-induced deaths occurred due to an opioid, including both prescription and illegal opioid drugs. Stratifying by drug type, prescription opioid-involved death rates decreased by nearly 7%, and heroin-involved death rates decreased by over 6%, whereas synthetic opioid-involved death rates (excluding methadone) increased by over 15%.
Historically, there have been three major waves of opioid overdose deaths in the late 20th century and the early 2000s. Throughout this time, prescription and illicit opioid overdoses have claimed the lives of nearly 500,000 people.
Increased prescription of opioids in the 1990s led to the first wave of the opioid epidemic, characterized by prescription opioid overdose deaths including natural opioids, semi-synthetic opioids, and methadone. The second wave began in 2010, characterized by rapid increases in overdose deaths involving heroin. The third wave began three years later in 2013, marked by significant increases in overdose deaths involving synthetic opioids, particularly the illegal drug fentanyl. Now, fentanyl is often marketed along with other illicit drugs like heroin, counterfeit pills, and cocaine. From 2013 to 2019, overdose deaths involving synthetic opioids increased twelve-fold, with 36,000 deaths in 2019 alone.
The COVID-19 pandemic has worsened the opioid crisis by accelerating the rate of opioid-related deaths. The Centers for Disease Control and Prevention (CDC) recorded over 81,000 drug overdose deaths occurring in the US in the 12 months ending in May 2020, which was the highest number of overdose deaths ever recorded in a 12-month period. Due to the disruption that COVID-19 has caused in peoples’ daily lives, the circulation of synthetic opioids in particular has gained considerable traction.
Synthetic opioids (primarily fentanyl) appeared to be the primary driver of the increases in overdose deaths, increasing 38.4 percent throughout the aforementioned 12-month period compared to the year before. The CDC has worked to combat the manufacture and widespread distribution of synthetic opioids during COVID-19 by promoting education and expanding distribution of naloxone and other preventative medications, as well as improving both diagnosis and early intervention resources for individuals with a high risk of developing substance use disorders.
Congress has been working on legislation to combat the opioid epidemic. In October 2018, Congress passed the SUPPORT for Patients and Communities Act (HR 6). This bipartisan law included several provisions to combat the opioid crisis by advancing treatment and recovery initiatives, improving prevention, protecting communities from synthetic drug distribution, and bolstering efforts to fight deadly illicit synthetic drugs like fentanyl. The following provisions were included:
- Increased the availability of medication-assured treatment (MAT) for opioid addictions by expanding the type of health providers that can distribute it
- Broadened medicaid eligibility for foster care youth
- Required states to make medicaid coverage include MAT
- Advanced telehealth resources for addicts
- Required manufacturers to alter opioid packaging so doctors could only prescribe 3 or 7 day quantities instead of 30 day-quantities
- Allocated $20 million to states to develop treatment programs
The SUPPORT Act was the last major opioid-related bill to pass Congress. Besides federal legislation, community programs have been created to provide local support. The Rural Communities Opioid Response Program is multi-year initiative providing millions of dollars in grants to public and private entities in rural communities (schools, churches, etc) to develop programs that combat the opioid epidemic, including planning grants, implementation grants, Medication-Assisted Treatment (MAT) Expansion grants, Neonatal Abstinence Syndrome grants, and psychostimulant support.
The Florida Department of Children and Families established the Florida’s State Opioid Response Project, which provides a comprehensive array of evidence-based prevention, medication-assisted treatment (MAT), and recovery support services to address the opioid epidemic, focusing primarily on the distribution of naloxone (Narcan). Likewise, the California MAT Expansion Project focuses on providing MAT to populations with limited or no MAT access, including rural areas and American Indian/Native Alaskan tribes.
In the United States, approximately 50,000 people died from opioid-related overdoses in 2019. Opioid abuse and addiction, which includes prescription pain medications, heroin, and synthetic opioids like fentanyl, is a severe national epidemic that has a negative impact on public health as well as social and economic well-being. The Centers for Disease Control and Prevention have reported that the Opioid Epidemic has impacted adults between ages 25-54 the most.
Opioids can cause respiratory problems as a result of their pharmacological effects, and an opioid overdose can result in death. Drug use is responsible for roughly 500,000 fatalities worldwide. More than 70% of these deaths are caused by opioids, with overdose accounting for more than 30% of those deaths.
FAIR Health's research, The Opioid Crisis Among the Privately Insured, detailed the epidemic's impact on healthcare services, citing a 3,203 percent increase in claim lines with an opioid dependency diagnosis from 2007 to 2014. The number of opioid-related emergency room visits and inpatient stays has increased considerably, as have the number of dangerous infections caused by opioid use, such as endocarditis and hepatitis C. Total hospital expenditures associated with opiate overdoses are projected to exceed $2 billion per year.
Risks of Indifference
The number of opioid overdoses has risen in various nations in recent years, owing in part to increased use of opioids for chronic pain management and the growing availability of very strong opioids on the illegal drug market. In the U.S., the number of persons dying from opioid overdose grew by 120 percent between 2010 and 2018, with synthetic opioids, such as fentanyl and its analogues, accounting for two-thirds of opioid-related overdose deaths in 2018.
The treatment of opioid use disorder is predicted to become more difficult if the COVID-19 pandemic continues. Existing patients may not adhere to treatment and may relapse if their stress levels rise, and physician monitoring and drug programs may be undermined as clinics and physician practices struggle to meet patient demands.
Opioid treatment centers were not eligible for any of the $50 billion in cash set aside for Medicare providers when lawmakers approved the Coronavirus Aid, Relief, and Economic Security (CARES) Act in March. As a result, the employees at these critical centers—often underfunded and understaffed—became ill or left to care for loved ones.
Furthermore, job loss and illness have increased the likelihood of relapse and death among people already at risk of opioid addiction. A patient's ability to obtain a prescription for addiction-management medicines is a major issue. Many clinics, understandably, only give their patients one pill per day, but as the pandemic has necessitated physical separation and lack of physical touch, it has become increasingly difficult for people to obtain their prescription. Patients are discouraged from getting their daily dose because of huge queues and hours-long wait times. Only a few individuals are eligible for more than one dose per day, and only a few doctors are allowed to administer higher doses of opioid management medicine.
Republicans and Democrats tend to agree that something should be done about the opioid crisis - but they disagree on how.
The Leonard Davis Institute of Health Economics provides us with an analysis of state legislators opioid-related social media content that highlights partisan differences on the topic. Democratic legislators tend to focus their solutions around holding pharmaceutical companies accountable and treating Opioid Abuse Disorder (OUD). while Republican legislators spoke more about the illegal drug trade and the harsh criminalization of opioid possession and use.
Recent legislation, such as the SUPPORT for Patients and Communities Act, is a step in the right direction. More recently, the Budgeting for Opioid Addiction Treatment Act has been introduced and would impose an excise tax on the sale of any active opioid and would provide block grants to substance abuse treatment programs. In addition, the STOP Fentanyl Act of 2021 would work to establish programs that address fentanyl overdose and addictions. Upon implementation, this bill would effectively increase fentanyl surveillance and establish a program for federal, state, and local law enforcement agencies that would increase education on how to detect and handle fentanyl.
Individuals can encourage their local legislatures to vote on bills that work to overcome the opioid epidemic. Additionally, staying educated on the signs of an overdose, such as pinpoint pupils, slowed breathing, and loss of consciousness can save lives in emergency scenarios. The medical industry continues to work to advance research and education to address the opioid epidemic and co-prescribing naloxone can be the first step for those at risk.
The Opioid epidemic has been plaguing the world since the 1990s, and has had serious social and economic consequences. The ongoing COVID-19 pandemic has exacerbated the problem, and we have seen significant increases in the number of overdose deaths. Congress has noticed the issue and passed some legislation in response, such as the SUPPORT act. Community organizations have taken action as well. Stopping the spread of this epidemic is a community effort and requires individuals to stay updated and educated on how to identify and provide relief to those experiencing overdose.